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The Thirteen Moon/28-Day calendar is the perfect instrument for such a simple regis tration of harmony and synchronization order kamagra effervescent 100mg with amex erectile dysfunction medication insurance coverage. It should also be noted that in its math ematics the Thirteen Moon/28-Day calendar is a function of the 13:20 timing fre quency order kamagra effervescent 100 mg fast delivery erectile dysfunction icd 9 code 2013. This in itself establishes the Thirteen Moon/28-Day calendar as a perfect instrument of the Law of Time and as a function of the synchronic order of reality order kamagra effervescent 100 mg line impotence in the bible. Since the process of civilization represents a break from a long cycle generally undistinguished by the kind of perturbations that characterize history kamagra effervescent 100mg with visa erectile dysfunction treatment homeopathy, the analysis of the Law of Time assumes that in prehistory humans lived in relative harmony, and therefore that the humans tended to use harmonic instruments of time reckon ing. The humans living in greater harmony with the biospheric cycles would be disposed to be in greater unconscious or aboriginal attunement with the noosphere. Since the noosphere is regulated by the synchronic order of the universal 13:20 timing frequency, the humans would be more naturally disposed to devise, adopt, or intuitively utilize the time measure in greatest accord with this instinctual 13:20 noospheric timing ratio. This instrument of time measure would, of course, be the Thirteen Moon/2 8-Day calendar. It should also be noted that this calendar is a perfect solar-lunar measure; that is, it uses the even, regular lunar cycle of28 days as the standard of measuring the 365-day solar cycle of the Earth. A solar-lunar calendar will represent and reflect a balance of the solar-lunar, masculine and feminine qualities within the human being. It is important to bear in mind these considerations of calendars and their effect on shaping the human historical conscious ness and its psychological makeup. From this perspective, history is, in fact, a process of falling away from the perfection of harmonic standards. Evidence exists that the Thirteen Moon/28-Day measure was widely known in prehistory. We find evidence of its use as a prehistoric synchronic measure in the remote past of China, in Polynesia, and scattered across late neolithic Europe and the Middle East. Among the Maya it was known as the Tun Uc, literally "moon count" or count of seven, while the living tradition of the Thirteen Moon/28-Day calendar is still continued in South America and in the British Isles, where it is known as the Druid Tree calendar. While the Druid calendar has no year count attached to it that would definitively testify to its prehistoric ancestry, the South American cal endar does. Known as the Pachacuti, the South American Thirteen Moon/28-Day calendar is currently in the year 5509, which places its origins at 3308 B. If we understand that calendars are genuine time-measuring devices meant to synchronize us with the cosmic order within the biosphere, and that calendars are thereby programming devices, we may then say that a calendar of perfect harmony can have no history. In other words, by its harmony such a calendar is always in tune with the cosmos, which is beyond history. History can only be a function of a dishar monic programming, not in sync or even at odds with the laws of natural time. From the point of view of timing devices, there are two factors in the establish ment of history. The first is the 12:60 program established 5,000 years ago with the division of the day into 24 hours, 60 minutes, 60 seconds, based on the 360-degree division of the circle. The other factor is the use of a purely lunar calendar that is difficult to reconcile with the actual measure of the solar year. The purpose of the 12:60 measure was to establish a timing standard that was actually a pseudosolar calendar to assert male intellectual dominance. The Babylonian (and later, Egyp tian) calendar consisted of twelve 30-day cycles = 360 days = 360 degrees, plus an extra 5-day cycle. The 30-day measure is not actually a natural one, being a half day more than the synodic lunar measure, but one that conforms to the hexagisimal (6-based) mathematics of the circle. Its ultimate descendent, as we shall see, is the twelve month Julian/Gregorian system. Its measure, however, is that of eighteen 20-day cycles (18 x 20 = 360) plus the 5-day cycle (uayeb), the 20-day cycle (vinal) being a mathematical function of the 13:20 frequency. In addi tion, the Maya had the measure of the tun, the 360-day count of which is precisely the same as that of the degrees of the circle. It was the tun that the Maya used to measure the thirteen baktun count, which actually consists of5,200 tun (5,125 solar years). The purpose of this measure was to provide an exact harmonic standard for the measure of history that, we may recall, is the duration of artificial time. It is very relevant that the harmonic standard of the thirteen baktun Wave Harmonic of history is the 360-day tun, the actual temporal equivalent of the degrees of a circle in space. The precise measurement of the cycle of artificial time, which turned out to be anything but har monic, could yet be measured with a harmonic unit that reflects both the circle and the mathematical perfection of the Law of Time. How better to coordinate the entire cycle of artificial time than by the tun, a unit of measure that reflects the 360-degree circle, the basis of the original error in artificial time? As we will later observe, the fact that the Law of Time coordinates even the cycles of artificial time is also evident in the analysis of the timing of the fatal flaw of the Twin Towers apocalypse. While the Babylonians began to apply a hexagisimal time-reckoning device based on spatial metrics of the circle, another factor became predominant in the Old World: the rise of the synodical lunar calendar as the exclusive measure of time. The synodi callunar calendar is purely lunar in that it is not evidently or perfectly harmonized with the 365-day measure of the solar cycle-a fact of great consequence for the development of mainstream civilization. The Babylonian calendar, with its abroga tion of the thirteen perfect 28-day months, established the pseudosolar twelve-month measure. This twelve-month measure conformed to the lunar measure of twelve synodic lunations per lunar year. And in reality, although we tend to think of the moon as feminine, the knowledge of the synodic measure, the cycle from new moon to new moon, became the exclusive province of a male priest class that used the lunar calendars to capture and control the feminine principle, and to oppress women in general.

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This provides In this Report, all incidence and incidence, mortality, and prevalence mortality rates are age-standard estimates for 27 site-specifc can ized. The un rate that a population would have When both incidence and mortality derlying principle in the estimation if it had a standard age structure. The time points); age has a powerful results are more accurate or less infuence on the risk of cancer, Bar charts accurate for different countries, de and populations differ with respect pending on the extent and accuracy to their age distribution. In the chapters in Section cept for China, are available only at for all sites combined, are shown 5, maps, pie charts, and time trend the national level. As annual Oakland, California; Detroit, Michi data for Uganda were not available, gan; Seattle?Puget Sound, Wash natural cubic spline interpolation ington; and Atlanta, Georgia). Cancer Mortality for Selected Sites in 24 Countries (1950? graphs (time trends or bar charts) 57). Department of Public Health, Tohoku as the scales used on the vertical University of Medicine, Sendai, Japan. Available at Locally weighted regression ministrative Region and Shanghai). Lung cancers from rate is proportional to the fourth pow dominant cause of lung cancer smokers exhibit up to 10 times er of age in never-smokers, and the worldwide. Other causes of lung as many mutations as tumours excess in smokers is proportional to cancer include radon, occupa from never-smokers. Smoking exerted a steeper to indoor air pollution, including risk gradient on squamous cell car There are four major histological second-hand tobacco smoke cinoma and small cell lung cancer types of lung cancer: adenocarci and emissions from household than on adenocarcinoma [3]. These tumours are are evident before the onset of clini cinoma has been distinguished defned primarily by morphology; cal disease (see Earliest molecular from non-small cell lung carcino however, in the past 10 years these evidence of tobacco-induced injury ma, which includes the histologi tumours have started to be classifed in the airway). Smoking cessation cal types of adenocarcinoma, according to immunohistochemical efforts have resulted in a growing squamous cell carcinoma, and and genetic characteristics as well. Further nonsmokers, particularly those with subtyping is increasingly done Etiology adenocarcinoma histology. Global distribution of estimated age-standardized (World) incidence frequent cancer worldwide. Age-standardized rates vary 80-fold internationally, are highest in North America, Europe, and East Asia, and tend to still be relatively low in many African countries and some Asian countries. In men, incidence rates have peaked in a number of highly developed countries at a late stage of the tobacco epi demic, while rates continue to rise among women. Radon is also identifed carcinogens encountered at highest pounds [5], not only specifc chemi as a risk factor for lung cancer [7]. Estimated global number of new cases and deaths with proportions by major world regions, for lung cancer in both sexes combined, 2012 Chart 5. Age-standardized (World) incidence rates per 100 000 by year in selected populations, for lung cancer in 100 000 by year in selected populations, for lung cancer in men, circa 1975?2012. Such fndings involve outdoor A genetic basis of susceptibility Thoracic Society, and European air pollution (see Biomarkers of air to lung cancer generally, as distinct Respiratory Society classifcation of pollution). Categories of air pollu from susceptibility to particular tu lung adenocarcinoma [17]. The term tion recognized to cause lung cancer mour types, has been extensively bronchioloalveolar carcinoma? is no also include exposure to second longer used. Large, collaborative hand tobacco smoke and to emis In small biopsies or cytology genome-wide association studies sions from household combustion of specimens, a tumour is classifed have identifed three separate loci coal [10,11]. In tumours that lack acetylcholine receptors and telo causation of lung cancer by arsenic any clear adenocarcinoma or squa merase production. Rare familial cases occur, and com Studies of single-nucleotide poly p63 or p40). However, in the past decade, the distinction between adenocarci noma and squamous cell carcinoma has been increasingly recognized because of major differences in ge netics and also in responses to spe cifc therapies [14]. Therefore, lung cancers are increasingly classifed according to molecular subtypes, predicated on particular genetic alterations that drive and maintain lung tumorigenesis. Such driver mutations, and the associated con stitutively active mutant signalling proteins, are critical to tumour cell survival, leading to the development of novel targeted therapies. While most of these genomic signalling pathways among high that the cellular injury produced by alterations (including those involved risk smokers that can be reversed smoking involves the whole respi in xenobiotic metabolism and oxida with chemopreventive agents that ratory tract. This molecular feld and in telomerase activity of non associated with the increased risk of injury has recently been extended cancerous bronchial epithelial cells of smoking-related lung disease in to chronic obstructive pulmonary [1]. The molecular field of injury that is induced among airway epithelial and degree of epithelial cell injury cells throughout the respiratory tract. Recent studies have indi cated that the gene expression re sponses to smoking in the bronchial airway also occur in the extratho racic airway epithelium that lines the mouth and nose [3]. This has led to the promise of genomic biomarkers of tobacco exposure and disease risk that can be developed in these non-invasive biosamples and can be applied to large-scale population based studies. This is necessary to these tumour cells form papillae lacking fibrovascular cores. The tumour cells Adenocarcinoma in situ is an ad have abundant apical mucin and small, basally oriented nuclei.

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The pro efforts designed to order kamagra effervescent 100 mg otc erectile dysfunction pump how to use prevent cancer lished for decades purchase 100 mg kamagra effervescent overnight delivery impotence questions, or shorter pe cess requires many years discount 100 mg kamagra effervescent visa erectile dysfunction in young, beginning [2] discount kamagra effervescent 100 mg visa erectile dysfunction at age 19. The ability to mobilize large num riods, and some have achieved with the development and testing of bers of health-care professionals, signifcant reductions in cancer a comprehensive quality assurance other stakeholders, and the target specifc mortality. Colorectal system to ensure the provision of population itself in collective actions cancer screening programmes cost-effective, affordable, and ac focused on a common goal is cru have been introduced more ceptable services for the entire target cial to the success of any screening recently. Screening can stim screening conducted as planned political commitment, engage ulate health systems development fulfls the key performance targets ment of civil society, competent and raises the level of awareness and is likely to be cost-effective. It oversight, and adequate, sus of cancer symptoms among health may take several years to collect suf tainable resources. A quality-assured population be drawn about routine implementa have the authority to coordinate based screening programme raises tion and to make any necessary ad all activities essential for provi the standards of cancer diagnosis justments to the screening protocol sion of screening services, in and treatment throughout the medi warranted by the pilot results. Professionals trained studies are also needed to provide monitoring, and other aspects of to meet the standards of the screen information on the cost-effective quality assurance. Immunochemical faecal occult blood testing kit used in the Lampang Province national or regional programmes for colorectal cancer screening programme in Thailand. In most high-income countries, the burden of cancer has resulted in coordinated efforts to implement population-based screening for all of the tumour types for which evi dence-based methods are currently established (breast, cervical, and colorectal cancer). In other coun tries, due to the comparatively long period required to successfully es tablish population-based screening programmes, time trends in cancer incidence and mortality should be taken into account when prioritizing potential target cancers for screen ing [1]. On this basis, cancers cur rently suitable for screening in low and middle-income countries include, for example, cervical can cer in sub-Saharan Africa, India, and Latin America; breast cancer in Latin America, the Middle East, and some countries in Asia; and colorec tal cancer in countries in transition, an individual country. Before ful pilot studies, gradual, quality In a fully established programme, a commitment is made to the roll controlled roll-out of the programme the proportion of the expenditure out of a screening programme, the across the country begins, with the devoted to quality assurance in a potential cost-effectiveness of the health-care system controlling the high-resource setting should be no programme in the country should be pace of programme expansion, with less than 10?20% [7]. If pilot studies particular reference to specialized proportion of these resources are indicate that the cost per year of life training of staff and investment in in required for well-organized informa saved by a given intervention is less frastructure. The entire process of tion systems, such as those used than the per capita gross national programme implementation rarely by cancer and screening registries, product, a screening programme can takes less than 10 years [1]. Programme tation of population-based cancer for example through training of com resources include a dedicated screening programmes, efforts to petent staff. When access to prompt budget and staff, computerized in improve early detection of cancer diagnosis and treatment is available, formation systems, and registries should be integrated into national alternative strategies of early detec for cancer, population, and screen comprehensive cancer control plans tion can be considered in countries ing, all based on individual data that establish overall priorities in the where low incidence rates do not [5]. Successful implementation of health-care agenda and take into ac yet justify population-based screen effective screening programmes count all relevant activities, such as ing programmes for asymptomatic Chapter 4. The authors considered that the most reliable es timates of reduction in breast cancer mortality were 25?31% for women invited for screening and 38?48% for women actually screened [21]. Population-based colo and the performance of breast self cervical cancer in the medium and rectal cancer screening programmes examination, suggesting a potential long term [14,15]. Morocco is currently establish mammography were initiated in of performance have recently been ing universal access to comprehen Europe, Canada, and Australia in developed for the population-based sive cancer diagnosis, treatment, the late 1980s after randomized programmes in Europe based on re and palliative care according to the controlled trials showed the eff sults achieved in randomized trials 2010?2019 national cancer control cacy of screening [16,17]. This includes a nationwide population-based breast screening early detection programme for clini programmes were running or be Fig. Now that cer screening programmes were screening has been performed for launched in middle and high-income more than two decades in several countries in the 1960s to 1980s, for population-based programmes in cervical cancer screening. These Europe, methodologies used to programmes were based on con estimate the impact of screening ventional cytology, and many led to and the level of overdiagnosis have reductions of 50?80% in cervical been evaluated using data from ser cancer mortality within two to three vice screening programmes [19]. In Registry studies analysing popula recent years, primary cervical cancer tion breast cancer mortality rates 332 and routine programmes [23]. Screening programmes in upper-middle-income countries Opportunistic, large-scale cervical cancer screening has been conduct ed in some upper-middle-income countries for several years. The resulting impact on cervical cancer incidence and mortality has been limited, due to poor coverage and lack of quality assurance in cytol ogy screening, suboptimal adher ence by screen-positive women to further diagnosis and treatment, and lack of information systems to moni tor progress and assess impact. Implementation of ed and shows potential to increase vices currently preclude introducing acetic acid-based screening may cervical screening effectiveness by screening programmes in most of improve development of screening increasing participation, especially these countries. In recent positive women, as well as the lim fordable viral tests become widely years, many of these programmes ited impact of Pap smear screening available. Improving breast spread, but population-based breast with acetic acid have been evalu awareness may facilitate earlier clin cancer screening programmes have ated as alternative methods, and ical diagnosis among symptomatic yet to evolve in many upper-middle single-visit approaches, involving women in such settings, but these income countries. Colorectal cancer diagnosis and treatment of screen efforts may be counterproductive if screening is less widespread; a na positive women in the same sitting the women cannot obtain timely di tional programme exists in Uruguay. For the same reason, systematic ap Screening programmes in Recent results from such studies proaches to early detection based lower-middle-income and have prompted the introduction of on breast examination and imaging low-income countries visual inspection of the cervix with methods are required in countries Cancer screening programmes are acetic acid screening programmes that have an increasing burden of operational in very few lower-middle in Bangladesh [27], Tamil Nadu state breast cancer but that currently lack income and low-income countries in in India, Thailand [28], and Zambia adequate diagnostic and therapeu Africa, Asia, Central America, and [29], as well as demonstration tic services [30,31]. Population the Caribbean, despite the high risk programmes in 43 counties of 31 based colorectal cancer screening Chapter 4. A woman being screened for stomach cancer at the Osaka Cancer Prevention lower-middle-income country, with and Detection Center, in Japan, in research directed towards the development of a the exception of Thailand, where population-based protocol for this tumour type. Outlook Breast, cervical, and colorectal cancer screening programmes have been improved globally through re search in terms of quality inputs, effciency, and effectiveness. New research fndings have catalysed the planning and organization of new screening programmes in some countries [32]. Research has indicat ed the effcacy of mammography and faecal occult blood screening and paved the way for population-based screening programmes. Screening approaches for other tumour types, such as lung, ovarian, oesophageal, stomach, and prostate cancer, are low and middle-income countries, and appropriate diagnostic and ther currently being investigated in re where cancers are mainly detected apeutic services universally avail search settings (Fig. Recent Provision of adequate resources will cancer screening programme in research may lead to new approach be decisive. Unless es to early detection and treatment International cooperation can these initiatives prove their effcacy, using improved awareness of symp enable countries to avoid common feasibility, and cost-effectiveness tomatic disease and population pitfalls in the implementation of in those settings, population-based based screening of asymptomatic screening programmes and other programmes are unlikely to be es people. Success in decreasing the bur share knowledge about successful Population-based screening den of cancer will depend on the methods and approaches.

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